​A review of previously published literature regarding health-related quality of life (HRQL) associated with food allergies, revealed a distinct gender bias. The study, published in Clinical and Experimental Allergy, showed that HRQL associated with food allergies, deteriorated more for females, than for males (Rosser, et al., 2024).[1] According to the original article, data for the study was gathered by doing systematic searches of Medline and Embase databases. The first search was conducted on April 4, 2022, and a second search was done on December 5, 2023, to provide updated data.

​As an online article published on the MedicalNewsToday website points out, 80% of patients who have an autoimmune disease are women (Pratt, 2024, February 1).[1] The reason for this gender bias has been unexplained until recently, when researchers discovered a connection with a genetic process unique to women, that occurs because of the DNA configuration that defines the difference between mammalian males and females. As the article points out, not only human females, but every biologically female mammal has two X chromosomes, while men have one X and one Y chromosome. Although it's obviously possible to live without a Y chromosome, as females do, it's not possible to live without an X chromosome, because the X chromosome contains the coding for hundreds of genes that define the production of critical proteins that are essential for the proper operation of our body.